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1. Bianchi, Antonio. Maca Lepidium meyenii Boletín. Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, vol. 2, núm. 3, mayo, 2003, pp. 30-36. Universidad de Santiago de Chile Santiago, Chile 

2. Gonzales, G. F. (2012). Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the Peruvian highlands. Evidence-Based Complementary and Alternative Medicine, 2012.

Lepidium meyenii (maca) is a Peruvian plant of the Brassicaceae family cultivated for more than 2000 years, which grows exclusively in the central Andes between 4000 and 4500 m altitude. Maca is used as a food supplement and also for its medicinal properties described traditionally. Since the 90s of the XX century, an increasing interest in products from maca has been observed in many parts of the world. In the last decade, exportation of maca from Peru has increased from 1,415,000 USD in 2001 to USD 6,170,000 USD in 2010. Experimental scientific evidence showed that maca has nutritional, energizer, and fertility-enhancer properties, and it acts on sexual dysfunctions, osteoporosis, benign prostatic hyperplasia, memory and learning, and protects skin against ultraviolet radiation. Clinical trials showed efficacy of maca on sexual dysfunctions as well as increasing sperm count and motility. Maca is a plant with great potential as an adaptogen and appears to be promising as a nutraceutical in the prevention of several diseases.

3. Stone, M., Ibarra, A., Roller, M., Zangara, A., & Stevenson, E. (2009). A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. Journal of ethnopharmacology, 126(3), 574-576.

Aims of the study

Maca (Lepidium meyenii Walp) is consumed both as a sports supplement by strength and endurance athletes, and as a natural stimulant to enhance sexual drive. However, whether or not the postulated benefits of maca consumption are of scientific merit is not yet known. The aim of the study was therefore to investigate the effect of 14 days maca supplementation on endurance performance and sexual desire in trained male cyclists.

Materials and methods
Eight participants each completed a 40 km cycling time trial before and after 14 days supplementation with both maca extract (ME) and placebo, in a randomised cross-over design. Subjects also completed a sexual desire inventory during each visit.

ME administration significantly improved 40 km cycling time performance compared to the baseline test (P = 0.01), but not compared to the placebo trial after supplementation (P > 0.05). ME administration significantly improved the self-rated sexual desire score compared to the baseline test (P = 0.01), and compared to the placebo trial after supplementation (P = 0.03).

14 days ME supplementation improved 40 km cycling time trial performance and sexual desire in trained male cyclists. These promising results encourage long-term clinical studies involving more volunteers, to further evaluate the efficacy of ME in athletes and normal individuals and also to explore its possible mechanisms of action.

4. Brooks, N. A., Wilcox, G., Walker, K. Z., Ashton, J. F., Cox, M. B., & Stojanovska, L. (2008). Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause, 15(6), 1157-1162.

Objective: To examine the estrogenic and androgenic activity of Lepidium meyenii (Maca) and its effect on the hormonal profile and symptoms in postmenopausal women.

Design: Fourteen postmenopausal women completed a randomized, double-blind, placebo-controlled, crossover trial. They received 3.5 g/day of powered Maca for 6 weeks and matching placebo for 6 weeks, in either order, over a total of 12 weeks. At baseline and weeks 6 and 12 blood samples were collected for the measurement of estradiol, follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin, and the women completed the Greene Climacteric Scale to assess the severity of menopausal symptoms. In addition, aqueous and methanolic Maca extracts were tested for androgenic and estrogenic activity using a yeast-based hormone-dependent reporter assay.

Results: No differences were seen in serum concentrations of estradiol, follicle-stimulating hormone, luteinizing hormone, and sex hormone-binding globulin between baseline, Maca treatment, and placebo (P > 0.05). The Greene Climacteric Scale revealed a significant reduction in scores in the areas of psychological symptoms, including the subscales for anxiety and depression and sexual dysfunction after Maca consumption compared with both baseline and placebo (P < 0.05). These findings did not correlate with androgenic or α-estrogenic activity present in the Maca as no physiologically significant activity was observed in yeast-based assays employing up to 4 mg/mL Maca extract (equivalent to 200 mg/mL Maca).

Conclusions: Preliminary findings show that Lepidium meyenii (Maca) (3.5 g/d) reduces psychological symptoms, including anxiety and depression, and lowers measures of sexual dysfunction in postmenopausal women independent of estrogenic and androgenic activity.

5. Dini, A., Migliuolo, G., Rastrelli, L., Saturnino, P., & Schettino, O. (1994). Chemical composition of Lepidium meyenii. Food chemistry, 49(4), 347-349.

Lepidium meyenii Walpers, a tuber of Andine origin still cultivated in Peru for local preparation, was studied. The carbohydrate, lipid, protein, fibre and also the amino-acid, fatty acid, mineral and sterol fractions were determined. The results show that the tuber is nutritionally interesting. Alkaloid-like compounds were also found. It is concluded that this tuber can be a food source in countries, where economic and technological conditions are inadequate to combat malnutrition.

6. Večeřa, R., Orolin, J., Škottová, N., Kazdová, L., Oliyarnik, O., Ulrichová, J., & Šimánek, V. (2007). The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant foods for human nutrition, 62(2), 59-63.

This work focused on the effect of maca on lipid, anti-oxidative, and glucose parameters in hereditary hypertriglyceridemic (HHTg) rat. Maca (1%) was administred to rats as a part of a high-sucrose diet (HSD) for 2 weeks. Rosiglitazone (0.02%) was used as a positive control. Maca significantly decreased the levels of VLDL (very low density lipoproteins), LDL (low density lipoproteins), and total cholesterol, and also the level of TAG (triacylglycerols) in the plasma, VLDL, and liver. Maca, as well as rosiglitazone, significantly improved glucose tolerance, as the decrease of AUC (area under the curve) of glucose showed, and lowered levels of glucose in blood. The activity of SOD (superoxide dismutase) in the liver, the GPX (glutathione peroxidase) in the blood, and the level of GSH (glutathione) in liver increased in all cases significantly. Results demonstrate that maca seems to be promising for a positive influence on chronic human diseases (characterized by atherogenous lipoprotein profile, aggravated antioxidative status, and impaired glucose tolerance), and their prevention.

7. Wang, Y., Wang, Y., McNeil, B., & Harvey, L. M. (2007). Maca: An Andean crop with multi-pharmacological functions. Food Research International, 40(7), 783-792.

Maca (Lepidium meyenii walp.), a biennial herbaceous plant of the family Brassicae, which is cultivated mainly in the central Andes of Peru, has been used as both a food and a traditional medicine in the region for over 2000 years. The subterranean parts of the plant have long been used as a staple foodstuff by indigenous peoples in the Andean region, but the plant is also valued for its medicinal role. As is usual with many traditional “folk” medicines, many claims have been made regarding the efficacy of maca in treating a wide range of illnesses and medical conditions. However, in the 20th century most scientific attention has been focused in the areas where the pharmacological actions of maca seem most strongly attested, these include, enhancement of sexual drive in humans, increasing overall vigour and energy levels, and increasing sexual fertility in humans and domestic livestock. Since the early days of the 20th century numerous scientific studies have been carried out into the basis of its pharmacological action in these areas. In this review, the composition and pharmacological function of maca are systematically discussed. Additionally, the current discussion surrounding its mode of action in the areas listed above is also presented.

8. Balick, M., & Lee, R. (2002). Maca: from traditional food crop to energy and libido stimulant. Alternative therapies in health and medicine, 8(2), 96-98.

9. Valerio, L. G., & Gonzales, G. F. (2005). Toxicological aspects of the South American herbs cat’s claw (Uncaria tomentosa) and maca (Lepidium meyenii). Toxicological reviews, 24(1), 11-35.

Recent exceptional growth in human exposure to natural products known to originate from traditional medicine has lead to a resurgence of scientific interest in their biological effects. As a strategy for improvement of the assessment of their pharmacological and toxicological profile, scientific evidence-based approaches are being employed to appropriately evaluate composition, quality, potential medicinal activity and safety of these natural products. Using this approach, we comprehensively reviewed existing scientific evidence for known composition, medicinal uses (past and present), and documented biological effects with emphasis on clinical pharmacology and toxicology of two commonly used medicinal plants from South America with substantial human exposure from historical and current global use: Uncaria tomentosa (common name: cat’s claw, and Spanish: uña de gato), and Lepidium meyenii (common name: maca). Despite the geographic sourcing from remote regions of the tropical Amazon and high altitude Andean mountains, cat’s claw and maca are widely available commercially in industrialised countries. Analytical characterisations of their active constituents have identified a variety of classes of compounds of toxicological, pharmacological and even nutritional interest including oxindole and indole alkaloids, flavonoids, glucosinolates, sterols, polyunsaturated fatty acids, carbolines and other compounds.
The oxindole alkaloids from the root bark of cat’s claw are thought to invoke its most widely sought-after medicinal effects as a herbal remedy against inflammation. We find the scientific evidence supporting this claim is not conclusive and although there exists a base of information addressing this medicinal use, it is limited in scope with some evidence accumulated from in vitro studies towards understanding possible mechanisms of action by specific oxindole alkaloids through inhibition of nuclear factor (NF)-κB activation. Although controlled clinical studies have demonstrated reduction in pain associated with cat’s claw intake in patients with various chronic inflammatory disorders, there is insufficient clinical data overall to draw a firm conclusion for its anti-inflammatory effects. An important observation was that experimental results were often dependent upon the nature of the preparation used. It appears that the presence of unknown substances has an important role in the overall effects of cat’s claw extracts is an important factor for consideration. The available animal toxicological studies did not indicate severe toxicity from oral intake of cat’s claw preparations but rather were suggestive of a low potential for acute and subacute oral toxicity, and a lack of evidence to demonstrate genotoxic potential and mutagenic activity.
Maca is a clear example of a herb with substantial medicinal use in traditional herbal medicine by indigenous cultures in South America since the first recorded knowledge of it in the seventeenth century. The hypocotyls of maca are the edible part of the plant used for nutritional and proposed fertility-enhancing properties. Maca has been described to possess many other medicinal properties in traditional herbal medicine but only a few of them have been well studied scientifically. Published clinical studies of maca seem to be related to its property as a nutrient, for male fertility and for energy. There are inadequate data regarding the precise mechanism of action of maca. Some studies suggest that secondary metabolites found in maca extracts are important constituents responsible for its physiological effects. Maca has been reported in the scientific literature to have a low degree of acute oral toxicity in animals and low cellular toxicity in vitro.
An important finding unveiled by this review is the importance of standardisation in quality and additional basic and clinical research to scientifically validate and understand composition, biological activity, safety and risk. Development of a comprehensive pharmacological and toxicological profile through critical evaluation of existing and future experimental data, especially carefully conducted clinical studies would facilitate the scientific evidence-based approach to understanding potential biological effects of these major traditionally based herbals in current global use.

10. Valentová, K., & Ulrichová, J. (2003). Smallanthus sonchifolius and Lepidium meyenii-prospective Andean crops for the prevention of chronic diseases. Biomed Papers, 147(2), 119-130.

Smallanthus sonchifolius (yacon) and Lepidium meyenii (maca) were the traditional crops of the original population of Peru where they are also still used in folk medicine. These plants are little known in Europe and Northern America although at least yacon can be cultivated in the climatic conditions of these regions. This article deals with the botany and the composition, the structure of main constituents, biological activity of these plants and the cultivation of yacon in the Czech Republic. The potential of yacon tubers to treat hyperglycemia, kidney problems and for skin rejuvenation and the antihyperglycemic and cytoprotective activity of its leaves seems to be related mostly to its oligofructan and phenolic content, respectively. Maca alkaloids, steroids, glucosinolates, isothicyanates and macamides are probably responsible for its aptitude to act as a fertility enhancer, aphrodisiac, adaptogen, immunostimulant, anabolic and to influence hormonal balance. Yacon and maca are already on the European market as prospective functional foods and dietary supplements, mainly for use in certain risk groups of the population, e.g. seniors, diabetics, postmenopausal women etc.

11. Lozano-Canales, A., Janampa-Santome, M., Clark, D., & Gonzáles, W. L. (2019). Seed weight predicts seedling emergence, and extremely acid soil and low availability of Phosphorus are associated with poor plant performances in Lepidium meyenii Walpers (maca). Scientia Horticulturae253, 341-348.

Lepidium meyenii Walpers (maca) is a Peruvian species cultivated in the high Andean region (ca. 4000 m.a.s.l.), highly praised for the nutritional properties of its hypocotyl. The benefits to human health and their relationship with the hypocotyl have been well investigated. However, few studies have addressed the factors affecting field crop performance and the improvement of agronomic practices. Here we evaluate the effect of soil properties (humidity, temperature, and fertility) and sowing method (ridge-furrow system and flat planting) on the biological performance of five seed accessions of maca in 6 experimental plots along an altitudinal gradient (3554–4442 m.a.s.l.). Plots located at both the lowest and highest altitudes had lower plant survival, vegetative growth, and hypocotyl size. Most of the differences among plots could be attributed to the acidity and the concentration of available hosphorus in the soil. In addition, low soil temperature and humidity negatively affected crop performance at different stages of plant development. The ridge-furrow system appeared to promote plant growth, although it did not favor plant survival under the unexpected climatic conditions experienced. Finally, seed weight was found to be a good predictor of seedling emergence and plant survival.


1 Wang, S., & Zhu, F. (2019). Chemical composition and health effects of maca (Lepidium meyenii). Food chemistry288, 422-443.

2 Yábar, E., Pedreschi, R., Chirinos, R., & Campos, D. (2011). Glucosinolate content and myrosinase activity evolution in three maca (Lepidium meyenii Walp.) ecotypes during preharvest, harvest and postharvest drying. Food Chemistry127(4), 1576-1583.

3 Vílchez Túpac, L. M., Guevara Pérez, A., & Encina Zelada, C. R. (2012). Influencia del tamaño de partícula, humedad y temperatura en el grado de gelatinización durante el proceso de extrusión de maca (Lepidium meyenii Walp). Revista de la sociedad química del Perú78(2), 126-137.

4 Ley, B. M. (2003). Maca!: Adaptogen and Hormonal Regulator. Bl Publications.

5 Meissner, H. O., Kapczynski, W., Mscisz, A., & Lutomski, J. (2005). Use of gelatinized maca (Lepidium peruvianum) in early postmenopausal women. International journal of biomedical science: IJBS1(1), 33.

6 Lična komunikacija sa vlasnikom firme koja poseduje sopstvene plantaže u Peruu, i proizvodi i sirovu i gelatinizovanu maku već 20 godina

7 French, D. (1984). Organization of starch granules. In Starch: Chemistry and technology (pp. 183-247). Academic Press.

8 Riaz, M. N. (Ed.). (2000). Extruders in food applications. CRC press.

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10 Case, S. E., Hamann, D. D., & Schwartz, S. J. (1992). Effect of starch gelatinization on physical properties of extrused wheat-and corn-based products. Cereal Chemistry69(4), 401-404.

11 Wang, Y., Wang, Y., McNeil, B., & Harvey, L. M. (2007). Maca: An Andean crop with multi-pharmacological functions. Food Research International40(7), 783-792.

12 Gonzales, G. F. (2012). Ethnobiology and ethnopharmacology of Lepidium meyenii (Maca), a plant from the Peruvian highlands. Evidence-Based Complementary and Alternative Medicine2012.

13 Johns, T. (1981). The anu and the maca. J Ethnobiol1, 208-212.

14 Brinckmann, J., & Smith, E. (2004). Maca culture of the Junin Plateau. The Journal of Alternative and Complementary Medicine10(3), 426-430.

15 Hermann, M. (1997). Andean roots and tubers: ahipa, arracacha, maca and yacon (Vol. 21). International Potato Center.

16 Smith, E. (2003). Maca root: Modern rediscovery of an ancient Andean fertility food. J Amer Herbalists Guild4(2), 15-21.

17  Valerio, L. G., & Gonzales, G. F. (2005). Toxicological aspects of the South American herbs cat’s claw (Uncaria tomentosa) and maca (Lepidium meyenii). Toxicological reviews24(1), 11-35.

18 Gonzales, G. F. (2010). Maca: del alimento perdido de los incas al milagros de los andes. estudio de seguridad alimentaria y nutricional. Segurança Alimentar e Nutricional17(1), 16-36.

19 Kos, J. (2015). Aflatoksini: analiza pojave, procena rizika i optimizacija metodologije određivanja u kukuruzu i mleku.

20 Alanya Tineo, J. P. (2018). Estudio de prefactibilidad para la instalación de una planta de producción de harina pre-gelatinizada de maca (Lepidium meyenii Walp) en Ayacucho.

21 Esparza, E., Hadzich, A., Kofer, W., Mithöfer, A., & Cosio, E. G. (2015). Bioactive maca (Lepidium meyenii) alkamides are a result of traditional Andean postharvest drying practices. Phytochemistry116, 138-148.

22 Zhang, S. Z., Yang, F., Shao, J. L., Pu, H. M., Ruan, Z. Y., Yang, W. L., & Li, H. (2020). The metabolic formation profiles of macamides accompanied by the conversion of glucosinolates in maca (Lepidium meyenii) during natural air drying. International Journal of Food Science & Technology, 55(6), 2428-2440.

23 Sifuentes-Penagos, G., León-Vásquez, S., & Paucar-Menacho, L. M. (2015). Estudio de la Maca (Lepidium meyenii Walp.): cultivo andino con propiedades terapéuticas. Scientia Agropecuaria6(2), 131-140.

24 Shapiro, T. A., Fahey, J. W., Wade, K. L., Stephenson, K. K., & Talalay, P. (2001). Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans. Cancer Epidemiology and Prevention Biomarkers10(5), 501-508.

25 Fahey, J. W., Zalcmann, A. T., & Talalay, P. (2001). The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry56(1), 5-51.

26 Higdon, J. V., Delage, B., Williams, D. E., & Dashwood, R. H. (2007). Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. Pharmacological research55(3), 224-236.

27 Meissner, H. O., Mscisz, A., Mrozikiewicz, M., Baraniak, M., Mielcarek, S., Kedzia, B., … & Pisulewski, P. (2015). Peruvian Maca (Lepidium peruvianum):(I) Phytochemical and genetic differences in three Maca phenotypes. International journal of biomedical science: IJBS11(3), 131.

28 Slominski, B.A., Campbell, L.D., (1989). Formation of indole glucosinolate breakdown products in autolyzed, steamed and cooked brassica vegetables. J. Agric. Food Chem. 37, 1297–1302

29 Conaway, C. C., Getahun, S. M., Liebes, L. L., Pusateri, D. J., Topham, D. K., Botero-Omary, M., & Chung, F. L. (2000). Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutrition and cancer38(2), 168-178.

30 Rouzaud, G., Young, S. A., & Duncan, A. J. (2004). Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers. Cancer Epidemiology and Prevention Biomarkers13(1), 125-131.

31 Zhang, L., Cao, J., Hao, L., & Kang, C. (2017). Quality evaluation of Lepidium meyenii (Maca) based on HPLC and LC-MS analysis of its glucosinolates from roots. Food Analytical Methods10(7), 2143-2151.

32 Li, G., Ammermann, U., & Quirós, C. F. (2001). Glucosinolate contents in maca (Lepidium peruvianum Chacón) seeds, sprouts, mature plants and several derived commercial products. Economic botany55(2), 255-262.

33 Gan, J., Feng, Y., He, Z., Li, X., & Zhang, H. (2017). Correlations between antioxidant activity and alkaloids and phenols of maca (Lepidium meyenii). Journal of Food Quality2017.

34 Meissner, H. O., Reich-Bilinska, H., Mscisz, A., & Kedzia, B. (2006). Therapeutic Effects of Pre-Gelatinized Maca (Lepidium peruvianum Chacon) used as a non-hormonal alternative to HRT in perimenopausal women-Clinical Pilot Study. International journal of biomedical science: IJBS2(2), 143.

35 Meissner HO, Mscisz A, Piatkowska E., et al. Peruvian Maca (Lepidium peruvianum) – II: Phytochemical Profiles of Four Prime Maca Phenotypes Grown in Two Geographically-Distance Locations. Int J Biomed Sci. 2016;12(1) 9-24.

36 Meissner H.O., Kedzia B., Mrozikiewicz P.M., et al. Short- and Long- Term Physiological responses of Male and Female Rats to Two Dietary Levels of Pre-Gelatinised Maca (Lepidium peruvianum Chacon). Int J Biomed Sci. 2006; 2: 15

37 Lozano-Canales, A., Janampa-Santome, M., Clark, D., & Gonzáles, W. L. (2019). Seed weight predicts seedling emergence, and extremely acid soil and low availability of Phosphorus are associated with poor plant performances in Lepidium meyenii Walpers (maca). Scientia Horticulturae253, 341-348.

38 Stone M, Ibarra A, Roller M, Zangara A, Stevenson E. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen. J Ethnopharmacol. 2009 Dec 10;126(3):574-6. doi: 10.1016/j.jep.2009.09.012. Epub 2009 Sep 23. PMID: 19781622.

39 Clément, C., Diaz, D., Manrique, I., Avula, B., Khan, I. A., Ponce Aguirre, D. D., … & Kreuzer, M. (2010). Secondary metabolites in maca as affected by hypocotyl color, cultivation history, and site. Agronomy Journal102(2), 431-439.

40 Lee MS, Lee HW, You S, Ha KT. The use of maca (Lepidium meyenii) to improve semen quality: A systematic review. Maturitas. 2016 Oct;92:64-69. doi: 10.1016/j.maturitas.2016.07.013. Epub 2016 Jul 21. PMID: 27621241.